2025
January – March
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Even though it's Saturday, a computer is still working hard for my project at work. This is one of the satisfying parts of the tech and machine learning field.
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In the dot com bust, many people left the tech industry. Coding with AI will drive a similar attrition.
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Manuel is a great follow for programming with AI. This note about a distributed mental model caught my eye. Some frameworks and systems are going to be more amenable to high level descriptive instructions in Cursor vs more narrow and prescriptive. I've already noticed subtle… ht…
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real-time response --> delayed receipt report Agents and deep research interactions are normalizing a delay in responses. For years, application developers have had <200 ms responses as an unwritten goal. The normalization of this delay presents interesting opportunities.
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This is great. We used to rack and stack servers for our managed hosting service at ViaWest, and there was a lot of satisfaction in connecting the virtual world back to the physical world. Plus, systems like PXE boot were really fun to build. I do miss some of the data center… h…
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When I wrote Basic programs for my TI-99/4A, they were gone when we turned it off. When we typed in longer programs on an Apple II (from magazines), we eventually learned how to save them as files on a floppy disk. It's the same. https://x.com/jxnlco/status/1901702040587501873
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Read ./plan.md Go
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The way people use and react to programming with AI (cursor etc) is really interesting to observe. It seems to be saying as much about programmers as it is about the technology.
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This post makes a great connection between agency and locus of control. Understanding locus of control can be very useful in life. https://x.com/karpathy/status/1894099637218545984
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Agents are neat, but... In modern business, software has effectively orchestrated the parts of work where things are digitized, structured, and procedural. Now, LLMs (and vision, audio, and action models) are simultaneously opening up new interfaces, access to unstructured infor…
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My machine learning professor @isbellHFh reinforced how little the code for our projects mattered. We could write it, borrow it, steal it, whatever. He was teaching us the value of the outcomes and analysis. I keep thinking about that as I experience AI assisted programming.
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An AI or agent system that helps you get more work done is nice. But what about an agent that helps you live a better life and become a better version of yourself.
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Agents are conversation and low friction delegation https://x.com/cmcollier/status/1890833753506767003
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The new MVP in software is minimum viable prompting.
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Conversation is the universal interface
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The practice of programming is getting refactored. Tired: REPL Wired: RIPL Read Imagine Prompt Loop
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RegFormer: A Single-Cell Foundation Model Powered by Gene Regulatory Hierarchies I'm working through this new sc paper week. In this one, they are adjusting things to help leverage gene regulatory understanding. I like the sound of that. https://www.biorxiv.org/content/10.1101/2…
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Cursor's new tag line: Let go, and let vibe
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Tonight, on a trip to the grocery store, I wrote a telegram + openai bot program on my phone using Claude. Later I setup the env, got a bot token, and fired it up. There were only two minor bugs, and now I can get to the fun parts. Unreal.
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Well this raises some questions. Time to look more closely at the eval methods? Are there similar risks in the single cell foundation models? https://www.biorxiv.org/content/10.1101/2024.12.18.628606v1
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This is a really interesting paper, which takes the ideas from diffusion models (often applied to image data), and adapts them to single cell genetic expression data. Really nice crossover. scDiffusion: conditional generation of high-quality single-cell data using diffusion mode…
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Wow. It feels like my relationship with the process of programming is about to change significantly. Today I used @cursorai on real code and challenges.
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Ok. It's time. https://x.com/MLStreetTalk/status/1883561139088355598
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Your digital shadow can be used to build a better you.
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The process of writing well is similar to the process of programming well.
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Imagine when we can deploy a small LLM almost anywhere, in the same way sqlite is used. https://x.com/softwaredoug/status/1878219479286456709
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It's been a while since I read the book, but it's been on my mind lately. Sher describes a kind of person, called a Scanner, that has a wide breadth of interests. This can be a really frustrating experience, but it doesn't have to be. https://amzn.to/3C0yUVD
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In this paper, @LinkedIn describes their updated hybrid search platform for content search. It's a nice overview of a concrete implementation of some modern search techniques. My favorite parts are the various personalization approaches integrated into the re-ranking layers. It…